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In patients who had taken oral OKT3, the drug was well-tolerated without serious treatment-related AEs or cytokine release syndrome, demonstrated biological activity through increased T-cell proliferation and anti-inflammatory gene expression changes, and achieved clinical response in 3 of 6 patients at week 3, though only modest endoscopic improvement occurred and effects appeared transient after treatment discontinuation (87)
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As a key component in detoxification pathways, GSH can facilitate the safe excretion of metabolic wastes and heavy metals
